In patients with CRC who are undergoing adjuvant chemotherapy, it has been observed that the presence of F. nucleatum infection leads to a reduction in the effectiveness of 5-Fluorouracil (5-FU) treatment by regulating the baculoviral IAP repeat containing 3 (BIRC3) through the TLR4/NF-B signaling pathway (329, 385). This evidence concerns the gene TLR4 and colorectal carcinoma.