Chemerin exerts its actions by binding to the CMKLR1 (chemerin chemokine-like receptor 1).6 A second receptor, CCRL2 (CC motif chemokine receptor-like 2), functions as a chaperone receptor, concentrating chemerin locally and thereby allowing optimal chemerin-CMKLR1 interaction.6 CMKLR1 activation is responsible for the deleterious effects observed in pregnant mice with placental chemerin overexpression.10 This receptor also upregulates constrictor responses.16 Consequently, it might be beneficial to reduce placental and circulating chemerin in preeclampsia. The gene discussed is RARRES2; the disease is preeclampsia.