Circulating chemerin is, at least partly, adipose tissue-derived, and this may explain its correlation with BMI.6,7 However, the placenta is another well-known source of chemerin, and thus, its upregulated levels in preeclampsia are likely of placental origin.10,13 Indeed, the elevated chemerin release from preeclamptic placentas supports this concept. Here, RARRES2 is linked to preeclampsia.