By contrast, the overexpression of circYthdc2 or Linear-FLAG-Ythdc2-170aa both could significantly inhibit the expression levels of interferon IFN1, inflammatory cytokines (TNF-α), and antiviral genes such as myxovirus resistance protein 1 (Mx1), ISG15, and Viperin after SCRV infection (Fig. 3E). Here, ISG15 is linked to infection.