To further support these observations, we induced SGs formation in pancreatic cancer cells obtained from Pdx1-cre;LSL-KrasG12D/INK4a/Arf’fl/fl/NUPR1+/+ or Pdx1-cre;LSL-KrasG12D/INK4a/Arf’fl/fl/NUPR1-/- mice (Cano et al, 2014). This evidence concerns the gene NUPR1 and familial pancreatic carcinoma.