As expected, restored VHL expression in VHL-deficient 786-O cells reduced tumor volumes (Fig. 5F), weight (Fig. EV5F), and expression of Ki67 (Fig. EV5G) and LC3B-II, with a corresponding increase in p62 expression (Fig. 5G) in tumor tissue, and these changes were substantially abolished by Beclin1 P54A expression (Figs. 5F,G and EV5F,G). This evidence concerns the gene SQSTM1 and neoplasm.