VHL and neoplasm: As expected, restored VHL expression in VHL-deficient 786-O cells reduced tumor volumes (Fig. 5F), weight (Fig. EV5F), and expression of Ki67 (Fig. EV5G) and LC3B-II, with a corresponding increase in p62 expression (Fig. 5G) in tumor tissue, and these changes were substantially abolished by Beclin1 P54A expression (Figs. 5F,G and EV5F,G).