In contrast, VHL depletion in VHL-proficient SN12C and TK-10 renal carcinoma cells (Appendix Fig. S1E) dramatically enhanced glucose deprivation-induced autophagy as reflected by enhanced PI(3)P production (Appendix Fig. S1F) and elevated conversion of LC3B-I to LC3B-II with decreased p62 expression (Fig. 1G; Appendix Fig. S1G). This evidence concerns the gene VHL and renal carcinoma.