We showed that Beclin1 P54A knock-in expression in VHL-proficient SN12C cells increased tumor volumes (Fig. 5D), weight (Fig. EV5D), and expression of Ki67 (Fig. EV5E) and LC3B expression with a corresponding decrease in p62 expression (Fig. 5E) in tumor tissue. This evidence concerns the gene SQSTM1 and neoplasm.