PARG and breast carcinoma: For this purpose, we genetically depleted Parg in the Brca2−/−;Trp53−/− mammary tumor cell line KB2P1.21, derived from our K14cre;Trp53F/F;Brca2F/F mouse model for BRCA2-mutated breast cancer (Jonkers et al, 2001; Evers et al, 2008).