It has also been proposed that CRL2FEM1B might be involved in neurologic disorders, such as Alzheimer’s, by regulating the function of cyclin-dependent kinase 5 activator 1 (CDK5R1) (Chow et al, 2019; Draney et al, 2016; Liu et al, 2019; Moncini et al, 2016; Spreafico et al, 2018; Zeng et al, 2021). The gene discussed is CDK5R1; the disease is nervous system disorder.