EYA4 and cancer: Further, benzarone caused a dose-dependent elevation in cleaved PARP, indicative of cell death, and phosphorylation of H3 on S10, indicative of mitotic arrest, in cancer cell lines with high expression levels of EYA4 (HeLa), EYA1 (SKNAS), or both (SKNFI) (Supplementary Fig. 3D, E).