In this vein, it is also intriguing that a specific transport-defective isoform of APOE, APOE4 (the mammalian functional ortholog of GLaz36), is a major risk factor for Alzheimer’s disease and that additional Alzheimer’s disease-associated genes also alter the dynamics of neuron–glia lipid metabolism61. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.