Using T-leukemia NSG mouse model, we found that CD1a CAR-T cells effectively destroyed YAP1-KO T leukemic cells, but not the control leukemic cells, leading to the prolonged survival of the mice (Fig. 8a–c); however, this killing process was abrogated by Lat-A treatment (Supplementary Fig. 7a–c). The gene discussed is CD1A; the disease is leukemia.