ERBB2 and neoplasm: In the presence of T-DM1 or T-DXd treatments, sensitivity analyses demonstrated that parameters that have substantial impacts on tumor volume are associated with the unique mechanism of action of HER2-ADC, such as the internalization rate of ADC (kint_ADC), the proteasomal degradation rate of ADC (kdeg_ADC_2), and the efflux or permeation rate of payloads (kout_PL, kper_PL) (Fig. 6c and Supplementary Fig. S4c).