A key feature of the proximal colon cancers with BRAFV600E mutation is their increased likelihood to have the CIMP-H phenotype, leading to epigenetic silencing of critical tumor suppressors, including the key cell cycle checkpoint regulator CDKN2A, the Wnt-pathway regulators such as the SFRPs and SOX17, and developmental regulators including the key intestinal lineage determining homeobox TF, CDX218–20. This evidence concerns the gene CDKN2A and malignant colon neoplasm.