It is important to note that while the oncogenic HRAS(G12V) is the most common cancer-associated substitution and is also commonly used to induce malignant transformation of cells11, particularly in non-model organisms like naked mole-rats and blind mole-rats12,13, neoplastic transformation of cells may require species- or cell type-specific mutations of HRAS or other RAS members10,11. Here, HRAS is linked to cancer.