This results in misfolding and accumulation of mutant huntingtin protein in brain cells, including neurons, microglia, and astrocytes.232 In addition to motor, cognitive, and psychiatric abnormalities, HD patients experience a range of GI disturbances, including nutrient deficiency, diarrhea, and unintended weight loss.233,234 However, it was only recently that gut dysbiosis has been revealed in preclinical HD models and HD patients, and studies examining the interaction between gut microbiota and microglia remain absent. The gene discussed is HTT; the disease is Huntington disease.