The immune-enriched subtype (IM-S-3), containing most UPS samples, was characterized by the highest immune score, the presence of CD8 + T cells, CD4 + T cells, macrophages, etc., and increased expression of the immune evasion markers CD274 (PD-L1), CD80 (Fig. 5A, F, Supplementary Fig. 13E). This evidence concerns the gene CD4 and undifferentiated pleomorphic sarcoma.