After adjusting for potential confounding variables (including age, sex, BMI, HDL-c, TG, LDL-c, BUN, Scr, ALT, AST, family history of diabetes, smoking and drinking status), the results indicated a positive association between PP and the risk of prediabetes (HR 95% CI 1.19 (1.15–1.23), P < 0.001). The gene discussed is GPT; the disease is diabetes mellitus.