IFIH1 and idiopathic inflammatory myopathy: Of note, however, a subgroup of idiopathic inflammatory myopathies, known as clinically amyopathic dermatomyositis (CADM), are associated with antibodies against melanoma differentiation–associated protein 5 (MDA5), which is an RLR helicase and putative cytoplasmic receptor for SARS-CoV2.