Eventually, nine intersecting genes were obtained based on the intersections of the DEGs, AD-related module genes (WGCNA), and ICD-related genes (Fig. 5A), including P2RX7, NLRP3, HSP90AA1, TLR2, LY96, TLR4, IFIH1, NT5E and AIM2. This evidence concerns the gene TLR4 and Alzheimer disease.