The distribution of nine immune functions in the merged AD samples is presented in Fig. 10A. The findings of the immune function analysis exhibited significantly higher levels of APC co-stimulation, cytolytic activity, inflammation promotion, parainflammation, T cell co-inhibition, T cell co-stimulation, and type I and II IFN responses in the brain tissues of the patients with AD than in those of the healthy controls, implying that these functions were vital in AD progression (Fig. 10B). Here, IFNA1 is linked to Alzheimer disease.