HAMLET sensitivity was further modified by the glycolytic state of tumor cells as glucose deprivation sensitized tumor cells to HAMLET-induced cell death and in the shRNA screen, hexokinase 1 (HK1), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 and HIF1α, modified HAMLET sensitivity31. This evidence concerns the gene HIF1A and neoplasm.