Since the concomitant activation of STAT3, Src, YAP, and Notch were reported in IL-6ST-activated intestinal epithelial cells [24], we evaluated the levels of phosphorylated YAP1 (Tyr357), YAP, cleaved Notch1, and HES1 in FXR-silenced or -overexpressed NSCLC cells. The gene discussed is HES1; the disease is non-small cell lung carcinoma.