NR1H4 and non-small cell lung carcinoma: In line with this interpretation, FXR was found to promote tumor migration and invasion in bile acid-deprived pancreatic and clear-cell renal cancer [15, 30], consistent with our findings in NSCLC, but exerts an opposite effect in tumor metastasis in bile acid-enriched hepatocellular and colon carcinomas [31, 32].