In this regard, Bucheit et al. showed that nasal polyps from the AERD group had a higher frequency of plasma cells in addition to increased levels of local antibodies and a higher rate of antibody class switching compared with polyps from the non-AERD group [30], although in another study they found that class switching not only to IgE but also to IgG4 was higher in the AERD group of patients with CRSwNP with recurrent polyps. This evidence concerns the gene IGHE and Nasal polyposis.