Constitutive Stxbp1 heterozygous knock-out mice including Stxbp1tm1d/+ mice have frequent SWDs, the hallmark of absence seizures, as well as myoclonic seizures that manifest as involuntary muscle jerks associated with EEG discharges or a more severe form—sudden jumps (Kovačević et al., 2018; Miyamoto et al., 2019; Chen et al., 2020). The gene discussed is STXBP1; the disease is Generalized non-motor (absence) seizure.