Both models recapitulate nearly all features of STXBP1 encephalopathy, as they show early lethality, developmental delay, cognitive impairments, motor dysfunction, anxiety-like behaviors, hyperactivity, aggression, and epileptic seizures including spike-wave discharges (SWDs) and myoclonic seizures (Chen et al., 2020). Here, STXBP1 is linked to Cognitive impairment.