One of the core features of STXBP1 encephalopathy is intellectual disability (Stamberger et al., 2016; Abramov et al., 2021; Xian et al., 2022), which is recapitulated by the severe cognitive deficits in Stxbp1tm1d/+ and Stxbp1tm1a/+ mice (Chen et al., 2020). This evidence concerns the gene STXBP1 and Cognitive impairment.