The selective presence of myoclonic seizures in Viaat-cHet mice is consistent with the clinical and experimental data that impaired GABAergic synaptic transmission in the cortex, hippocampus, cerebellum, or basal ganglia can cause myoclonus (Lalonde and Strazielle, 2012), whereas the SWDs in Vglut2-cHet mice may be due to the impaired cortico-striatal glutamatergic neurotransmission (Miyamoto et al., 2019). The gene discussed is SLC17A6; the disease is early-infantile DEE.