Anxiety was reported in a subset of STXBP1 encephalopathy patients (Marchese et al., 2016; Suri et al., 2017), and several lines of constitutive Stxbp1 heterozygous knock-out mice including Stxbp1tm1d/+ and Stxbp1tm1a/+ show increased anxiety (Hager et al., 2014; Miyamoto et al., 2017; Kovačević et al., 2018; Chen et al., 2020). This evidence concerns the gene STXBP1 and Encephalopathy.