COL1A2 and acute-on-chronic liver failure: The analysis of GEO dataset (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139602) showed that the expression of Col1A2 (ID: 11715356_x_at) was significantly increased in patients with liver diseases, including compensated cirrhosis (CC) and acute and chronic liver failure (ACLF) (Fig. 1a and Additional file 1: Fig. S2).