Plasma angiogenin was associated with an increased risk of MACE, independent of demographic and cardiometabolic risk factors (adjusted HR 2.38, 95% CI 1.34–4.23, model 1) and remained statistically significant after further adjustment for eGFR and uACR, two strong risk factors for MACE among individuals with T2D (adjusted HR 1.90, 95% CI 1.02–3.53, model 2). Here, ANG is linked to type 2 diabetes mellitus.