CXCL8 and Cowden syndrome 1: In severe cases, SARS-CoV-2 infection is associated with overproduction of proinflammatory cytokines such as IL-2, IL-6, IL-7, IL-8, IFN-γ, TNF-α, transforming growth factor-beta (TGF-β), C-X-C motif chemokine ligand 8 (CXCL8), CXCL10, chemokine ligand 3 (CCL3), macrophage inflammatory protein-1 alpha (MIP-1α), and -1β, known as CS.