CNR1 and Abnormal renal physiology: Three studies [19, 23, 49] reported glomerular damage score found that the blockade or knockout of CB1 group could significantly reduce glomerular damage in renal dysfunction animals compared with the control group (Fig. 3D, 3 items, n = 87; SMD, − 1.28; 95% CI − 1.79 to − 0.77; P < 0.0001; I2 = 0%).