Two studies [24, 38] reported 24 h urine protein found that the activation of CB2 group could significantly reduce albuminuria in renal dysfunction animals compared with the control group (Fig. 5C, 2 items, n = 29; SMD, − 2.43; 95% CI − 4.63 to − 0.23; P = 0.03; I2 = 75%). Here, CNR2 is linked to Abnormal renal physiology.