Two studies [29, 45] reported ACR found that the blockade of CB2 group could no significantly change albuminuria in renal dysfunction animals compared with the control group (Fig. 7C, 2 items, n = 28; SMD, − 0.99; 95% CI − 6.82 to 4.83; P = 0.74; I2 = 95%). This evidence concerns the gene CNR2 and Abnormal renal physiology.