AKT1 and nonpapillary renal cell carcinoma: Secondly, we evaluated the effects of Pazopanib alone, LY-294002 (AKT inhibitor) alone, Rapamycin (mTOR inhibitor) alone or in combination with si-circPDHK1 on the tumor biological behavior of ccRCC cells through CCK8, EdU, and transwell assays.