CircSEMA4B encodes SEMA4B-211aa, which is expressed at a low level in breast cancer and exerts a tumor suppressor function in vivo and in vitro by complexing with free p85 to decrease the p85/p110 PI3-kinase complex, leading to the inhibition of AKT (Thr308) phosphorylation and the generation of PIP3 [51]. This evidence concerns the gene AKT1 and breast cancer.