Exos with specific cargoes [P-gp, Survivin, DNMT1, Annexin A3, ATP7A, ATP7B, MRP1, p-STAT3) and miRNAs (miRNA-222-3p, -214, -100-5p, -567, -155-3p, -21, -433, -21-3p, -1246, -223, -365, -19b, -20a, -32-5p, -501, -447-5p, -99a-5p, -125b-5p, -210 & and -155] can increase tumor cell resistance via engaging different mechanisms such as DNA repair, apoptosis inhibition, alteration of drug targets, and efflux, up-regulation of MDR and oncogenes, down-regulating of tumor suppressor genes, EMT induction, autophagy stimulation [23, 193]. The gene discussed is STAT3; the disease is neoplasm.