Increased numbers of immunosuppressive cells in the TME (M2 macrophages, N2 neutrophils, MDSCs, Treg cells), a Th1 to Th2 shift, inhibition of cytotoxic cell activities (CD8+ T cells, NK cells), or apoptosis of lymphocytes enable cancer cells to evade an antitumor immune response. This evidence concerns the gene CD8A and cancer.