AKT1 and neoplasm: CircRNAs carried by exosomes play a crucial part in CRC: exosomal circPACRGL promoted CRC cell proliferation, migration and invasion, as well as differentiation of N1 to N2 neutrophils, CRC cell excreted out tumor-suppressive circRHOBTB3 via exosome to sustain its fitness, exosomal circTUBGCP4 promotes vascular endothelial cell tipping and CRC metastasis by activating Akt signaling pathway [45–47].