In the malaria-infected samples, a subset of ICD genes, such as TNF, P2RX7,BAX, IFNG, PRF1, CALR, HSP90AA1, IL6, IFNGR1, IL17RA, ENTPD1, MYD88, CASP1, IL1B, LY96 and TLR4, exhibited significant upregulation. The gene discussed is TNF; the disease is malaria.