In the malaria-infected samples, a subset of ICD genes, such as TNF, P2RX7,BAX, IFNG, PRF1, CALR, HSP90AA1, IL6, IFNGR1, IL17RA, ENTPD1, MYD88, CASP1, IL1B, LY96 and TLR4, exhibited significant upregulation. This evidence concerns the gene PRF1 and malaria.