In the multivariable model, CRP, SII, CAR, CLR, MHR, and NHR were associated with an increased risk of breast cancer (for the highest quartile vs. lowest quartile, HRCRP=1.20, 95% CI = 1.12–1.28; HRSII =1.11, 95% CI = 1.04–1.18; HRCAR =1.20, 95% CI = 1.12–1.29; HRCLR =1.16, 95% CI = 1.09–1.25, HRMHR =1.15, 95% CI = 1.07–1.23; HRNHR =1.18, 95% CI = 1.10–1.26), while LMR was inversely associated with breast cancer (HR = 0.89, 95% CI = 0.84–0.94), with all P-trend < 0.001(Fig. 1, Supplementary Table 2). The gene discussed is CRP; the disease is breast cancer.