In those patients with an increased BNP, GPs should be careful prescribing negative inotropic agents (such as calcium antagonists) for treatment of hypertension and focus on ACE inhibitors or angiotensin receptor blockers, which have demonstrated efficacy in heart failure prevention.30 Moreover, high-risk patients with hypertension should receive more aggressive treatment strategies to achieve target blood pressures.39 This evidence concerns the gene ACE and Hypertension.