These included hypertrophic cardiomyopathy (HCM) variants (myosin-binding protein C, MYBPC3 p.R943X and tropomyosin 1, TPM1 p.K37E) and dilated cardiomyopathy (DCM) variants (RNA-binding motif protein 20, RBM20 p.R634Q, and phospholamban, PLN p.R14del)23 in genes affecting sarcomere contractile machinery and calcium homeostasis. This evidence concerns the gene TPM1 and dilated cardiomyopathy.