In literature, studies have noted structural changes within the intestine of patients with type 1 diabetes, as reflected by alterations in tight junctions as well as in microvilli.23 Levels of zonulin, a molecule resident in tight junctions, are upregulated in patients with type 1 diabetes, and this is associated with increased intestinal permeability.24 Increased intestinal permeability may facilitate the absorption of antigens which can injure pancreatic β cell,25 which would decrease glycemic control and increase HbA1c. The gene discussed is HP; the disease is type 1 diabetes mellitus.