Anti-inflammatory cytokines inhibit inflammatory activity or suppress the intensity of inflammation.4 Interleukin-1β (IL-1β) exerts a pro-inflammatory effect and plays a role in the pathogenesis of periodontitis.5 IL-10, on the other hand, is an anti-inflammatory cytokine and exerts a broad suppressive effect on the production of antigen presenting cells, Th2 cells, Th17 cells, and pro-inflammatory cytokines.6 Reactive oxygen species (ROS) are highly reactive oxygen products. This evidence concerns the gene IL1B and periodontitis.