IGHE and asthma: In clinical situations, the confirmation of sensitization using standard diagnostic tests (skin prick tests and/or measurement of sIgE) does not necessarily indicate that a patient's symptoms are caused by an IgE-mediated reaction [3,12▪]: in a proportion of patients with asthma and rhinitis, sensitization ascertained by standard tests may be a chance finding unrelated to the presence or severity of their lower or upper airway symptoms [13▪].