Two types of amyloid account for 95% of cardiac amyloidosis: light-chain amyloid (AL) due to immunoglobin light-chain deposition and transthyretin (TTR) cardiac amyloidosis (ATTR-CM), which can be due to hereditary mutation (hATTR) or wild-type transthyretin (wtATTR) [1]. The gene discussed is TTR; the disease is cardiac amyloidosis.