In the study, MUC1-C induced PBRM1 by E2F1-mediated activation at its promoters, allowing MUC1-C to form a complex with NRF2 and PBRM1 on the NRF2 target SLC7A11 to drive its transcription in human prostate cancer stem cells [46]. This evidence concerns the gene PBRM1 and Familial prostate cancer.