In this research, we identified ten genes (GYS1, LRPPRC, NCKAP1, NDUFA11, NDUFS1, NUBPL, OXSM, RPN1, SLC3A2, and SLC7A11) that are closely related to disulfidptosis as disulfidptosis-related genes (DRGs) and investigated them in a multi-omics approach to comprehensively analyze their role in ccRCC. Here, GYS1 is linked to nonpapillary renal cell carcinoma.