Notably, the proportion of neutrophils increased in the metastatic samples (Figure 2C and Supplemental Figure 3A), transcriptionally resembling tumor-associated neutrophils (TAN) (27–29), with a high expression of VEGFA, LGALS3, OLR1, PROK2, MMP9, and IL1RN (Supplemental Figure 3, B and C). This evidence concerns the gene PROK2 and neoplasm.