The more severe disease course is likely attributable to more severe bacteremia (Figure 2 and Supplemental Figure 1, right panel) and aggravation of systemic complications, as we previously observed in Myd88–/– mice (8) because intracranial complications were equally and significantly attenuated in Tlr2/4/13–/–, Tlr2/13–/–, and 3d/Tlr2/4–/– as compared with WT mice. The gene discussed is MYD88; the disease is bacterial infectious disease with sepsis.