Consistently, in our study, Tlr2/4–/– and Tlr2/3/4/7/9–/– mice displayed comparable phenotypes, while the phenotype of Tlr3/7/9–/– mice was largely indistinguishable from that of WT mice, arguing against a key role of TLR3, -7, and -9 in pneumococci sensing and thus meningitis pathology. The gene discussed is TLR2; the disease is meningitis.