TNF and systemic lupus erythematosus: As noted in Figure 2B, similar significant upregulation of chemokine (C-X-C motif ligand) CXCL family, chemokine (C-C motif) ligand family, IL, and TNF genes was induced across all treatment conditions, but a larger degree of upregulation was detected in SLE fibroblasts compared with healthy controls (FDR < 1 × 10–5).