The results showed that there were significant changes in physiological outcomes (body weight, BMI, liver fat score, AST, ALT, and ɣ-GT) and psychosocial outcomes (self-management, fatigue, depression, and quality of life) in the intervention group for 6 months, and the intervention-by-time interaction was effective for self-management and fatigue improvement. The gene discussed is GPT; the disease is major depressive disorder.