By contrast, IGs are found in patients’ PB in the following pathological conditions: acute infection, inflammation, tissue injury, intravascular hemolysis, acute hemorrhage, non-hematopoietic malignant tumor, hematological neoplasms and in those receiving granulocyte colony-stimulating factor (G-CSF) or granulocyte–macrophage colony-stimulating factor (GM-CSF) [5–13]. This evidence concerns the gene CSF3 and hematopoietic and lymphoid system neoplasm.