Although POU2F3-positivity might also indicate benign tumors, considering the significantly higher frequency in benign tumors, the facts that even aggressive salivary gland tumors can harbor POU2F3-positive, possibly tuft cells, and that tumor-associated tuft cells can influence cancer aggressiveness through paracrine mechanisms [45], POU2F3-positivity may provide new translational perspectives on the role of tuft cells in malignant salivary and nonsalivary tumors, rather than diagnostic aid. Here, POU2F3 is linked to tumor of salivary gland.