Because KIT and BCL2 are often highly expressed in POU2F3-positive tuft cell-like carcinomas [17, 19, 22], the same feature in WTs could suggest that non-neoplastic POU2F3-positive cells might express BCL2 and KIT via non-mutational, possibly epigenetic mechanisms that, in turn, might be smoking-related [43, 44]. Here, POU2F3 is linked to carcinoma.