VPS13C was recently identified as a genetic cause of early-onset PD (Darvish et al., 2018; Gu et al., 2020; Hopfner et al., 2020; Jansen et al., 2017; Lesage et al., 2016; Nalls et al., 2014, 2019; Pan et al., 2023; Schormair et al., 2018; Smolders et al., 2021), yet how loss-of-function of VPS13C leads to PD remains uncertain. Here, VPS13C is linked to Parkinson disease.