LRRK2 and Parkinson disease: Previous studies found that overexpression of various LRRK2 PD mutants decreased lysosomal size in comparison with LRRK2 WT (Eguchi et al., 2018), and decreased average lysosomal size was also observed in LRRK2 G2019S knock-in neurons from primary cultures (Schapansky et al., 2018).