VPS13C and Parkinson disease: However, as prior studies of VPS13C have been restricted to non-neuronal cells (Cai et al., 2022; Chen et al., 2022; Hancock-Cerutti et al., 2022; Hook et al., 2020; Kumar et al., 2018; Lesage et al., 2016; Yang et al., 2016), the underlying mechanisms of VPS13C-linked PD in human neurons have remained elusive.