Rare compound heterozygous and homozygous mutations in vacuolar protein sorting 13 homolog C (VPS13C) were identified in early-onset PD patients (Darvish et al., 2018; Lesage et al., 2016; Smolders et al., 2021), who presented clinically with rapid disease progression, early cognitive decline (Lesage et al., 2016), severe neuronal loss in the substantia nigra, and diffuse Lewy body disease (Lesage et al., 2016; Smolders et al., 2021). The gene discussed is VPS13C; the disease is Lewy body dementia.