We also found that NPC268 consistently harbors CN losses in three chromosomal arms (Supplementary Table S8) in both tumor and cell line, including the 9p21.3 co-deletion of CDKN2A and MTAP which is a common event in NPC, implying that NPC268 could be vulnerable to MAT2A inhibitors (55). The gene discussed is CDKN2A; the disease is nasopharyngeal carcinoma.