ARHGEF10 and cancer: After stringent filtering criteria and focusing on annotated cancer driver genes, seven SNVs were identified in AKT1 (p.E17K), PMS2 (p.L47V), CBL (p.D772E), FLT3 (p.D7G), CDH1 (p.R124H), ARHGEF10 (p.I175V), KAT6B (p.A854T; Fig. 5B; Supplementary Table S7; Supplementary Dataset S1).