To establish that IFN induction in response to alisertib is not limited to the reporter cell line, we performed RNA-seq on other colorectal cancer cell lines (LoVo, Ls174T, HT29, SW480, SW1417, and Ls123) treated with alisertib or decitabine (Fig. 3E; Supplementary Table S4). The gene discussed is IFNA1; the disease is colorectal cancer.