To create an endogenous type I IFN reporter, we chose the colorectal cancer cell line HCT116, which is highly efficient for CRISPR-based gene editing, and surveyed IFNα induction of canonical type I IFN target genes (IFIT1, IFIT2, IFIT3, IFI27, IRF7, OASL, RSAD2; Fig. 1A). The gene discussed is IFIT2; the disease is colorectal cancer.