In addition, we revealed that silencing of DR4 and DR5 protects against AβQ22 and Hcy mediated apoptosis, providing direct evidence that AβQ22 and Hcy operate through the same DR‐mediated apoptotic pathway to exacerbate cerebral EC apoptosis and that this specific apoptotic pathway may be a potential target for future therapeutic strategies to tackle the cerebrovascular damage induced by both amyloidosis and Hhcy. The gene discussed is TNFRSF10A; the disease is amyloidosis.